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Renal calculi or nephrolithiasis refers stone in the kidney-ureter-bladder (KUB) region. Calcium oxalate is the chief ingredient to form most of the calculi and kidney stone is one of the most common health problems in Bangladesh as well as in the world. Multiple risk factors play important role in the formation of stone including fatty foods, increased intake of NSAID, sedentary life and few chronic clinical conditions. Recurrent infection in the urinary tract and dull aching pain in the flank is a most common symptom along with difficulties in urine output and may lead to sudden obstruction of urine flow if not treated properly. Conventionally surgery is the most prescribed solution however, there are few tangles of this including fear to surgery, expenses, and recurrence. Therefore, finding an alternative, more beneficial and less expensive for patients is essential. The current case study involves a single case of ureteric calculi complicated with enlarged prostate, increased creatinine and previously diagnosed diabetes mellitus, where Hydrangea arborescence and Berbaris vulgaris used with a positive outcome. The detailed mechanism of these two could be determined with extensive study along with new verge of research get opened.