A Rare Case of Recurrent Blastomycosis in North America

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Zebi Fatima


Blastomycosis is a chronic granulomatous and suppurative mycoses caused by Blastomyces dermatitidis. The majority of cases show a primary pulmonary disease. We report a 65-year-old male patient with two painless, violaceous nodules over the left chest wall and right inner thigh. Initially, differential diagnoses of disseminated Blastomycosis, Pneumonia, and Diffuse large B-cell lymphoma made based on past and present clinical history and presentation. The final diag-nosis of disseminated with secondary cutaneous Blastomycosis in a followup case of Diffuse large B-cell lymphoma made based on skin biopsy, broncho-alveolar lavage, and bronchial brushing showing budding yeasts of Blastomyces. The patient responded well to therapy with Amphotericin B and Itraconazole along with intravenous methylprednisolone.

Blastomycosis, chronic granulomatous, Blastomyces dermatitidis

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How to Cite
Fatima, Z. (2020). A Rare Case of Recurrent Blastomycosis in North America. International Journal of Medical and Pharmaceutical Case Reports, 13(2), 1-8. https://doi.org/10.9734/ijmpcr/2020/v13i230115
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Donna C. Sullivan Rathel L. Nolan, III. Blastomycosis. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J, and editors. Harrison's principles of the internal medicine 19th Ed. McGraw-Hill Education. 2015;1137-39.

Litvinov IV, Paradis M, Sheppard DC. Blastomycosis in quebec, Canada: highlighting the importance of exposure to decaying wood in patients. J Infect Dis Ther. 2014;2:129.
DOI: 10.4172/2332-0877.1000129

Rao GR, Narayan BL, Durga Prasad BK, Amareswar A, Sridevi M, Raju B. Disseminated blastomycosis in a child with a brief review of the Indian literature. Indian J Dermatol Venereol Leprol. 2013; 79(1):92‐96.
DOI: 10.4103/0378-6323. 104676

Kumar A, Kunoor A, Eapen M, Singh PK, Chowdhary A. Blastomycosis misdiagnosed as tuberculosis, India. Emerg Infect Dis. 2019;25(9):1776‐1777.
DOI: 10.3201/eid2509.190587

Kline L. Cutaneous blastomycosis: A case report and review of the literature. Journal of the American Academy of Dermatology. 64(2); AB105

Dhamija A, D'Souza P, Salgia P, Meherda A, Kothiwala R. Blastomycosis presenting as solitary nodule: A rare presentation. Indian J Dermatol. 2012;57(2):133‐135.
DOI: 10.4103/0019-5154.94285

Yan L, Rohra P, Cheng L, Gattuso P. Pleural effusion in pulmonary and extrapulmonary blastomycosis. Acta Cytol. 2020;64(3):241‐247.
DOI: 10.1159/000500973

Smith JA, Kauffman CA. Blastomycosis. Proc Am Thorac Soc. 2010;7(3):173‐180. DOI:10.1513/pats.200906-040AL

Putman MS, Shah NS, Husain AN, David MZ. Extrapulmonary intrathoracic Blastomycosis: A case report and systematic literature review. JMM Case Rep. 2015;2(1).

Chapman SW, Dismukes WE, Proia LA, Bradsher RW, Pappas PG, Threlkeld MG, Kauffman CA. Clinical practice guidelines for the management of Blastomycosis: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis. 2008; 46:1801–1812.
DOI: 10.1086/588300