New Kid on the Block: A First Look at the Clinical Use of Pitolisant for Narcolepsy

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Andrea Cuamatzi Castelan Castelan
Virginia Skiba
Luisa Bazan
Kenneth Moss
Meeta Singh
Christopher Drake
Philip Cheng


Aims: Highlight pitolisant as an effective treatment for narcolepsy.

Case Report: We describe two patients treated with pitolisant. Patient A showed decreased daytime sleepiness and improved social functioning. Patient B struggled to find a dose that kept side effects at a minimum.

Discussion: This orphan drug has a unique mechanism of action, that combined with dosing flexibility allows for a treatment option that can better attend to individual differences in patient needs.

Conclusion: The use of pitolisant presents some benefits and challenges, nonetheless offering a promising treatment for narcolepsy.

Narcolepsy, pitolisant, excessive daytime sleepiness, histamine, histamine 3 receptor.

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How to Cite
Castelan, A. C. C., Skiba, V., Bazan, L., Moss, K., Singh, M., Drake, C., & Cheng, P. (2021). New Kid on the Block: A First Look at the Clinical Use of Pitolisant for Narcolepsy. International Journal of Medical and Pharmaceutical Case Reports, 14(1), 1-5.
Case Study


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