A Rare Incidence of Ethambutol Induced Toxic Optic Neuropathy
International Journal of Medical and Pharmaceutical Case Reports,
Ethambutol induces toxic optic neuropathy (EON), which most typically presents as bilateral symmetrical loss of vision and, due to a lack of early detection and adequate treatment, often causes serious irreversible visual impairment. EON is time and dose dependent. In this case report, we will discuss a 59-year-old female patient who came in with complaints of visual impairment, inclusive of a colour vision defect (dyschromatopsia) and blurred vision (scotoma). Her past medication history includes use of first-line anti-tubercular therapy (ATT) with four drugs: Rifampicin, Isoniazid, Ethambutol, and Pyrazinamide. Pyrazinamide was taken for two months, and other medications (Rifampicin, Isoniazid, and Ethambutol) were taken for a period of seven months. From this case report, we will get a clear picture necessitating continuous monitoring for ocular toxicity.
- Ethambutol-induced Optic Neuropathy (EON)
- Anti-Tubercular Therapy (ATT)
- Duration and dose dependent
How to Cite
Shamseeda, Jayasree. Epidemiological profile of extrapulmonary tuberculosis and its association with diabetes in tertiary care center in Northern Kerala. Int J Community Med Public Health [Internet]. 2022 [cited 2022 Nov 18];9(6):2590.
Song W, Si S. The rare ethambutol-induced optic neuropathy: A case-report and literature review. Medicine (Baltimore) [Internet]. 2017 [cited 2022 Nov 18];96(2):e5889.
Kesler A, Pianka P. Toxic optic neuropathy. Curr Neurol Neurosci Rep [Internet]. 2003 [cited 2022 Nov 18];3(5):410–4.
Sheng W-Y, Wu S-Q, Su L-Y, Zhu L-W. Ethambutol-induced optic neuropathy with rare bilateral asymmetry onset: A case report. World J Clin Cases [Internet]. 2022 [cited 2022 Nov 18];10(2):663–70.
Monika, Kumar J, Rathi M et.al. Ethambutol induced optic neuropathy: a rare case report. International Journal of Research and Review. 2020;7(2):13-17.
Sheng WY, Wu SQ, Su LY, Zhu LW. Ethambutol-induced optic neuropathy with rare bilateral asymmetry onset: A case report. World J Clin Cases 2022;10(2):663-670 [PMID: 35097092
Sen S, Mandal S, Banerjee M, Gk R, Saxena A, Aalok SP, et al. Ethambutol-induced optic neuropathy: Functional and structural changes in the retina and optic nerve. Semin Ophthalmol [Internet]. 2022;37(6):730–9.
Shah S, Adhikari YR, Paudel S, Sitaula S, Koirala B, Aryal S, et al. Optic neuropathy induced by ethambutol: A rare case from Nepal. Ann Med Surg (Lond) [Internet]. 2022;77(103637):103637.
Saxena R, Singh D, Phuljhele S, Kalaiselvan V, Karna S, Gandhi R, et al. Ethambutol toxicity: Expert panel consensus for the primary prevention, diagnosis and management of ethambutol-induced optic neuropathy. Indian J Ophthalmol [Internet]. 2021 [cited 2023 Jan 13];69(12):3734–9.
Islam IC, Umar BT, Minhajat R, Bukhari A, Sari DK, Kaelan C. Ethambutol effect on retinal and optic nerve structural changes in toxic optic neuropathy case: A literature review. Ophthalmol Res Int J [Internet]. 2022 [cited 2023 Jan 13];16(3):26–36.
Zhang X-H, Xie Y, Xu Q-G, Cao K, Xu K, Jin Z-B, et al. Mitochondrial mutations in ethambutol-induced optic neuropathy. Front Cell Dev Biol [Internet]. 2021;9:754676.
Abstract View: 61 times
PDF Download: 28 times