Open Access Case Report

D-Penicillamine in the Neonatal Period: Case Reports

Lajos Lakatos, György Balla, István Pataki, Zsuzsanna Vekerdy-Nagy, György Oroszlán

International Journal of Medical and Pharmaceutical Case Reports, Page 59-63
DOI: 10.9734/IJMPCR/2015/17239

D-Penicillamine (DPA) was first recognized as a potential benefit for neonatal hyperbilirubinemia (NHBI). During this time there was a remarkedly low incidence of retinopathy of prematurity (ROP) in the infants treated with DPA. Later, our studies were replicated in other institutes in Hungary, Poland, U.S.A., India and Mexico. It is important to note that there was no intolerance or short- or long-term toxicity of the medication, in spite of the fact that in the newborn period DPA was used 10-20 times higher doses (3 x 100 mg/kg bw./day IV for 3-7 days in the neonatal jaundice + once daily 50 mg/kg bw. IV until the end of the second week of life to prevent ROP) than those in adult. There were some very impressive cases in our practice in neonatology which deserved to be shown individually.

Open Access Case Study

Squamous Cell Carcinoma of the Larynx with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

M. Varela-Mariño, C. Dios Loureiro, J. Campos Franco, J. A. Díaz Peromingo

International Journal of Medical and Pharmaceutical Case Reports, Page 64-67
DOI: 10.9734//IJMPCR/2015/17739

Background: Paraneoplastic syndromes result from the secretion of hormones by a tumor giving rise to different syndromes. Lung carcinomas are the most common tumors causing paraneoplastic syndromes. The most common is the syndrome of inappropriate secretion of arginine vasopressin (SIADH).
Objective: To describe the case of a patient with larynx cancer and secondary SIADH and review of the literature.
Case Report: We present the case of an 80-year-old man with dry cough, dysphonia and severe hyponatremia. Physical examination was unremarkable. After admission he developed acute stridor and a tracheostomy was performed. Serum and urine analysis confirmed the presence of SIADH in the absence of renal, adrenal of thyroid dysfunction. No SIAHD producing drugs were reported. An ORL examination revealed the presence of a thickened area just below the right vocal cord. Hystopathological examination was suggestive of squamous cell carcinoma. After total laryngotomy, the final hystopathological exam reported the presence of a well differentiated squamous cell carcinoma. Hyponatremia was corrected with restriction of water intake to a maximum of 500 cc daily. Concomitant radiotherapy was administered.
Conclusion: Ectopic or inappropriate hormone secretion is uncommon in patients with the head and neck cancer. However, this condition should be included in the differential diagnosis of SIADH.

Open Access Case Study

An Unusual Self Inflicted Foreign Body in the Urinary Bladder

Gaurav Kesri, Prashant Gupta, Hoti Lal Gupta, Trilok Chand Sadasukhi, Krishan Kumar Dangayach

International Journal of Medical and Pharmaceutical Case Reports, Page 68-71
DOI: 10.9734/IJMPCR/2015/18139

Aim: The objective of this case report is to review the literature regarding various types of foreign bodies in the bladder, their mode of entry and appropriate management.
Presentation of Case: We report here the case of a 24 year old adult male with a foreign body in the bladder which was self introduced by him per-urethra for the purpose of sexual gratification.
Discussion: Presence of foreign bodies in the urinary bladder is not an uncommon occurrence and various cases highlighting different varieties of foreign bodies have been reported throughout the literature.
Conclusion: The foreign body was confirmed to be in the bladder by radiological imaging and removed uneventfully via urethrocystoscopy.

Open Access Case Study

Use of Human Embryonic Stem Cells (hESCs) in the Treatment of Glaucoma

Geeta Shroff, Lopamudra Das

International Journal of Medical and Pharmaceutical Case Reports, Page 72-76
DOI: 10.9734/IJMPCR/2015/18440

Glaucoma is a degenerative, optic neuropathy that results in damage to the optic nerve due to increased intraocular pressure (IOP). IOP can be influenced by hypertension, body mass index, atherosclerotic disease and diabetes. Cell based therapies play an important role in treating eye diseases, especially (irreversible loss of cells) due to glaucoma. We used human embryonic stem cell (hESC) therapy in two patients with glaucoma. hESCs are derived from a patented technology and are in use since the last 13 years. After the therapy, patients showed signs of improvement in their sight such as in peripheral vision, as well as in cognitive abilities like concentration and speech.

Open Access Case Study

Colonoscopy-induced Enteropathogenic Escherichia coli Bacteremia Diagnosed by Serum Polymerase Chain Reaction Method

Masaaki Minami, Teruko Ohkura, Takafumi Ando, Hidemi Goto, Michio Ohta

International Journal of Medical and Pharmaceutical Case Reports, Page 77-81
DOI: 10.9734/IJMPCR/2015/18449

We report the case of colonoscopy induced enteropathogenic Escherichia coli (EPEC) bacteremia by bacterial translocation. A 58-year old woman who complained of abdominal pain was performed colonoscopy. Intestinal mucosal culture by biopsy showed EPEC O18. She developed a high grade fever after colonoscopy. Although blood culture did not detect any bacteria, eaeA gene of EPEC was detected from patients’ serum by polymerase chain reaction (PCR). Though colonoscopy was performed again after receiving antibiotics, high grade fever was not seen. EPEC was not cultured from mucosa nor eaeA gene was not detected from sera. Serum PCR method is useful for detection of bacteremia.