Open Access Case Study

Atypical Hemolytic Uremic Syndrome and Chronic Ulcerative Colitis Treated with Eculizumab

Tennille N. Webb, Heidi Griffiths, Yosuke Miyashita, Riha Bhatt, Ronald Jaffe, Michael Moritz, Johannes Hofer, Agnieszka Swiatecka-Urban

International Journal of Medical and Pharmaceutical Case Reports, Page 105-112
DOI: 10.9734/IJMPCR/2015/18771

Background: Hemolytic-uremic syndrome (HUS) presents with hemolytic anemia, thrombo-cytopenia, and thrombotic microangiopathy of the kidney and usually results from Shiga-toxin induced activation of the alternative complement pathway. Gastroenteritis is a common feature of the Shiga-toxin producing Escherichia coli HUS, referred to as STEC-HUS. An inherited or acquired complement dysregulation may lead to HUS referred to as non-STEC or atypical (a)HUS. Although gastroenteritis is not a common presentation of aHUS, some patients develop ischemic colitis and may be misdiagnosed as acute appendicitis or acute ulcerative colitis (UC).
Case Diagnosis –Treatment: We present a patient with low circulating complement (C) 3 levels who developed aHUS in the course of chronic active UC. Resolution of renal and gastrointestinal manifestations in response to treatment with eculizumab, a humanized monoclonal antibody against terminal C5 protein suggests the role of alternative complement in the pathogenesis of both, aHUS and UC.
Conclusion: This case illustrates that dysregulation of the alternative complement pathway may manifest in other organs besides the kidney and that the circulating C3 levels do not correlate with the disease activity or the clinical response to eculizumab.

Open Access Case Study

Cesarean-Related Kocuria kristinae Bacteremia

Houqiang Su, Shuang Li, Zhiming Hao

International Journal of Medical and Pharmaceutical Case Reports, Page 113-116
DOI: 10.9734/IJMPCR/2015/18938

Kocuria kristinae infection is quite rare in clinical practice. Until now, only about 20 cases of Kocuria kristinae infection have been reported in immunocompromised individuals or in patients who have undergone surgery. Here we report a case of Kocuria kristinae bacteremia after cesarean section. The patient, a 28-year-old woman, experienced intermittent high fever for 2 months beginning 10 days after undergoing a cesarean section. Organ involvement was not observed in this patient. Repeated bacteria isolation from peripheral blood verified Kocuria kristinae infection. The patient recovered after 2 weeks of an intravenous levofloxacin and vancomycin treatment indicated by antibiotic sensitivity tests. The present report and previous literatures indicate that Kocuria kristinae infections occur not only in immunocompromised hosts but also in immunopotent individuals undergoing operations or interventional procedures. Clinicians should be aware that Kocuria kristinae is a potential pathogen in nosocomial infections.

Open Access Case Study

Mauriac Syndrome in a 35 Year Old Woman With Type One Diabetes Mellitus

Ferdane Sapmaz, Sebahat Başyiğit, Ismail Hakki Kalkan, Sefa Güliter, Işilay Kalan Sari

International Journal of Medical and Pharmaceutical Case Reports, Page 117-120
DOI: 10.9734/IJMPCR/2015/18813

Mauriac syndrome is a rare complication of type 1 diabetes mellitus. It is characterized by hepatomegaly, growth delay and the presence of elevated transaminases and serum lipids. Mauriac syndrome occurs in males and females equally, and is most common in adolescence, although there are reports in children as young as toddlers and in adults.

Here in we report a 35 year old type 1 diabetic patient was admitted to our clinic with elevated transaminases and hepatomegaly and  diagnosed with Mauriac Syndrome.

Open Access Case Study

Hibernoma at Base of Neck- A Rare Case in a Six Month Old Infant

Purnima Samayam, A. C. Ramesh, N. Sharath Chandra, Mallikarjun R. Patil, D. H. Prasanna

International Journal of Medical and Pharmaceutical Case Reports, Page 121-124
DOI: 10.9734/IJMPCR/2015/19187

Hibernomas are very uncommon soft tissue tumors. They are composed of brown fat. They are usually seen in adults in the fourth/ fifth decades according to published literature. Very few cases in Paediatric age group have been reported. We present a hibernoma presenting as a swelling on the posterior aspect of base of neck in a six month old infant.

Open Access Case Study

Childhood Autism in a 3-Year Old Male Nigerian Whose Mother was diagnosed with Hepatitis C Virus Infection during Pregnancy: A Case Report

M. N. Igwe, N. A. Ajayi

International Journal of Medical and Pharmaceutical Case Reports, Page 125-129
DOI: 10.9734/IJMPCR/2015/18371

Introduction: Childhood autism is a pervasive developmental disorder presenting with a distinct pattern of impairments in social relationships and communication with repetitive/stereotyped behaviour. Multiple aetiological factors have been established and viral infections that occur very early in development have been proposed as possible aetiological factors.

Case Presentation: This article reports a case of childhood autism in a 3-year old male Nigerian whose mother was diagnosed with hepatitis C virus (HCV) infection during pregnancy.

Conclusion: The observation in this case report of childhood autism in a 3-year old male Nigerian whose mother had HCV infection during pregnancy raises the question of a possible association between childhood autism and HCV.