Open Access Case Study

Lung Adenocarcinoma with Coexistent Primary Hyperparathyroidism

Tezcan Kaya, Ceyhun Varım, Ahmet Nalbant, Ali Tamer

International Journal of Medical and Pharmaceutical Case Reports, Page 1-4
DOI: 10.9734/IJMPCR/2016/22590

The simultaneous presence of lung carcinoma and primary hyperparathyroidism, both causative conditions for hypercalcemia, is quite rare. A 56-year-old woman was diagnosed with hypercalcemia, caused by asymptomatic primary hyperparathyroidism attributable to a parathyroid adenoma. During evaluation, a lung mass was detected and diagnosed as lung adenocarcinoma on biopsy. We report the coexistence of primary hyperparathyroidism with malignancy in a patient who has hypercalcemia.

Open Access Case Study

Extraosseous Gorlin Cyst: Case Report

Jessica Barbosa de Oliveira Gonçalves, Ellen Cristina Gaetti Jardim, Bruna Trazzi Pagani, Rogerio Leone Buchaim, Beatriz Flavia de Moraes Trazzi, Marcelo Morgueti, Daniela Vieira Buchaim, Marcelo Rodrigues

International Journal of Medical and Pharmaceutical Case Reports, Page 1-6
DOI: 10.9734/IJMPCR/2016/22326

The Calcifying Cystic Odontogenic Tumor (CCOT) was first described by Gorlin in 1962. Due to its clinical, radiographic, and histopathological variables, it presents a wide variety of terminologies. The present report presents an extraosseous lesion (unrelated to teeth) with totally atypical behavior and a large bone resorption area. Clinical examination revealed a slight bulging in the lower right region of the jaw, presenting pain on palpation and soft consistency, as well as liquid contents inside it. A panoramic radiograph evidenced the presence of large local bone resorption. After collection of the material for histopathological analysis, the diagnosis was calcifying odontogenic cystic tumor. The lesion is also known as oral tumor of Malherbe, atypical ameloblastoma, keratinizing ameloblastoma, ghost cells odontogenic carcinoma, and Gorlin’s cyst. Such diagnosis in the literature is important, as there is a wide variety of manifestations of these lesions, complicating the clinical diagnosis and the terminological standardization of the disease.

Open Access Case Study

Diverse Management of Cornual Ectopic Pregnancy: Review of 2 Cases

Madhusudan Dey, P. R. Lele, Shyamji Tiwari

International Journal of Medical and Pharmaceutical Case Reports, Page 1-5
DOI: 10.9734/IJMPCR/2016/22329

Aims: Cornual or interstitial pregnancy is a rare form of ectopic pregnancy with high maternal morbidity and mortality. Different medical approach may require managing this form of unusual ectopic pregnancies.

Presentation of Case: We hereby present two cases of cornual ectopic pregnancies, one of them managed conservatively by potassium chloride and methotrixate. The other patient underwent laparotomy due to haemodynamic instability. 

Discussion: Cornual ectopic pregnancy usually presents during late first or early second trimester but it may present as early as 6-8 week period of gestation. Early diagnosis allows a varied choice of treatment options with a high possibility of preserving fertility. Surgical management is reserved for late presentation and patients present with haemodynamic instability.

Conclusion: Cornual ectopic pregnancy can present very early in the first trimester. Local KCL with systemic methotrexate can increase the success rate of conservative management in cornual ectopic pregnancies presenting late at first trimester.

Open Access Case Study

Surgical Management of Oral Verrucous Carcinoma and Its Recurrence: A Case Report and an Update

Nikhil Srivastava, Akshay Shetty, Vijay Apparaju, Rahul Dev Goswami

International Journal of Medical and Pharmaceutical Case Reports, Page 1-6
DOI: 10.9734/IJMPCR/2016/22662

Aim: To enlighten and update the clinicians about the diagnosis and management of recurrent verrucous carcinoma.

Presentation of Case: A single case of Oral verrucous carcinoma of the alveolar ridge is reported. The patient was treated by surgical resection of the lesion there was neither local recurrence nor distant metastasis observed.

Conclusion: Oral verrucous carcinoma (OVC) is type of well differentiated squamous cell carcinoma. OVC generally is a slow grower and has a higher chance of local invasion then metastasis. Buccal mucosa and gingiva (usually mandibular) are the sites most commonly affected, and majority of the patients tend to be elderly and male. Surgical resection with sufficient safety margin is recommended.

Open Access Case Study

Coexistance of Masked Philadelphia Chromosome and BCR-ABL1 Rearrangement with JAK2 (V617F) Point Mutation-A Case Report

Semir Mešanović, Haris Šahović, Goran Šarkanović

International Journal of Medical and Pharmaceutical Case Reports, Page 1-7
DOI: 10.9734/IJMPCR/2016/22951

In accordance with the last World Health Organization (WHO) classification, myeloproliferative neoplasms (MPNs) are classified on the basis of the presence or absence of BCR-ABL1 gene transcript, or the presence or absence of Philadelphia chromosome (Ph) in the karyotype. Previously, from a diagnostics perspective, it was thought that the JAK2V617F point mutation and BCR-ABL1 rearrangement were used to differentiate and unmask chronic myelogenous leukemia (CML) from other MPNs (and vice versa). In contradiction with this opinion, to date, several cases with the coexistence of BCR-ABL1 fusion gene and JAK2V617F mutation in bone marrow and blood samples has been reported. With this case study we report  a rare case of essential thrombocytemia with masked Philadelphia chromosome harboring both BCR-ABL1 rearrangement and JAK2V617F point mutation, simultaneously.