This case report is about a 67-year-old female patient who presented with an unusual case of acute renal failure and leukocytoclastic vasculitis. The patient required emergency dialysis; an ultrasound-guided kidney biopsy revealed membranoproliferative glomerulonephritis type one, a condition where the immune system damages both the membrane and the mesangium of the glomerulus. This condition was treated with therapeutic plasma exchange, pulse steroid therapy, and Rituxan, which lowered creatinine levels and stimulated greater urine output. These treatments resulted in attaining acceptable creatinine levels and the patient’s subsequent discharge from the facility.
Vasculitis, a combination of disorders which affects and disrupts the blood vessels due to inflammation and abnormal immune system, may be predisposed to increased glucose in blood circulation commonly observed in a skin surface of extremities in other parts of the body as well. Multiple drugs have been introduced but unfortunately, the available treatments have several limitations including failure to control the inflammation, preventing multiple system involvements and various side effects, moreover, the complex condition may arise with increased glucose, thus, treatment with these medicines is not satisfactory. The current study involves three patients with different degrees of severity of cutaneous vasculitis have been treated conventionally with the lack of response. Combinatorial application of attenuated phosphorus and sodium sulfate engenders rapid remission from the further inflammation and eventually found curing the patients with no evidence of side effects. This alternative mode of treatment may provide a better insight to cure vasculitis efficiently. Thus, extensive study is required to explore the detailed mechanisms of the treatment with these attenuated medicines.
Introduction: Diverticular disease is said to be complicated when the acute inflammation of a diverticulum leads to perforation, bleeding, formation of abscesses, bowel wall strictures or obstruction. The vague clinical presentation and rarity of complications in our environment contributes largely to misdiagnosis of the condition.
Case Report: This report is the case of a 50-year-old male who presented multiple times to the general outpatient department of a teaching hospital in North Central Nigeria with insidious onset of malaise, intermittent fever, progressive weight loss ,left flank pain and swelling, low back and waist pain radiating to the leg .Different misleading diagnoses were made within the period .The final definitive diagnosis of complicated Diverticulitis with distant lumbar Spondylodiscitis and bilateral psoas abscess with epidural extension was made with Computer tomography, CT.
Conclusion: This case demonstrates the challenge of early diagnosis of Diverticular disease and highlights the need for vigilance on the path of physicians to recognize signs and symptoms of diverticulitis with the aim of preventing its complications. There is also need for early and appropriate imaging.
Acute renal failure (ARF) is a rare phenomenon when it occurs with viral infections. Most of these cases are seen in critically ill patients and result in negative outcomes due to multiple organs involved with associated hypotensive shock that is one one the major contributors to acute tubular necrosis [11]. We are reporting a case of a young non-pregnant female who developed swine flu and had multisystem organ failure requiring mechanical ventilation. She developed acute renal failure requiring renal replacement therapy and aggressive supportive care. Her kidney function recovered over 6 weeks ending the need of hemodialysis (HD).
Introduction: Oseltamivir is an antiviral drug, used for influenza treatment. Neurological side effects of this drug, including hypothermia and respiratory arrest, were demonstrated in animal models.
Case Presentation: We reported a case of an elderly male who presented with influenza B pneumonia and respiratory failure. He received high dose and extended duration of Oseltamivir. He developed hypothermia and central hypoventilation, complicated with prolonged weaning. At that time, there were no sedative and neuromuscular blocking agents, and no evidence of brain stem dysfunction and endocrine crisis. Concerning of rare reported adverse reactions of Oseltamivir in animal models, this drug was discontinued. Consequently, his symptoms improved and he was successfully liberated from mechanical ventilation.
Conclusion: We hereby report a case of Oseltamivir associated respiratory suppression and hypothermia in human.
